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Regorafenib hydrochloride
CAS No. 835621-07-3
Regorafenib hydrochloride ( BAY73-4506 hydrochloride )
产品货号. M16096 CAS No. 835621-07-3
Regorafenib hydrochloride (BAY73-4506) is a potent, orally active multikinase inhibitor.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥243 | 有现货 |
|
| 10MG | ￥381 | 有现货 |
|
| 50MG | ￥786 | 有现货 |
|
| 100MG | ￥1191 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Regorafenib hydrochloride
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Regorafenib hydrochloride (BAY73-4506) is a potent, orally active multikinase inhibitor.
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产品描述Regorafenib hydrochloride (BAY73-4506) is a potent, orally active multikinase inhibitor that potently inhibits endothelial cell kinases in biochemical and cellular kinase phosphorylation assays with nanomolar range (IC50=3-200 nM); inhibits VEGFR1/2/3, PDGFRβ, FGFR1, KIT, RET and B-RAF etc.; exhibits potent dose-dependent TGI in various preclinical human xenograft models in mice.Colon Cancer Approved
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同义词BAY73-4506 hydrochloride
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通路Angiogenesis
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靶点VEGFR
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受体VEGFR
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研究领域Cancer
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适应症Colon Cancer
化学信息
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CAS Number835621-07-3
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分子量519.28
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分子式C21H16Cl2F4N4O3
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纯度>98% (HPLC)
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溶解度DMSO: ≥ 5.6 mg/mL
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SMILESCNC(=O)C1=NC=CC(=C1)OC2=CC(=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F)F.Cl
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化学全称2-Pyridinecarboxamide, 4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-3-fluorophenoxy]-N-methyl-, hydrochloride (1:1)
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Wilhelm SM, et al. Int J Cancer. 2011 Jul 1;129(1):245-55.
2. Mross K, et al. Clin Cancer Res. 2012 May 1;18(9):2658-67.
3. Abou-Elkacem L, et al. Mol Cancer Ther. 2013 Jul;12(7):1322-31.
2. Mross K, et al. Clin Cancer Res. 2012 May 1;18(9):2658-67.
3. Abou-Elkacem L, et al. Mol Cancer Ther. 2013 Jul;12(7):1322-31.
产品手册
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